"Wadannan nasarorin galibi suna amfana daga sabbin fasahohi, ingantaccen gudanarwa da samar da kore."Zhang Ge ya ce, "Godiya ga kokarin Deebio na samun inganci, samfuran bio-enzyme API suna da fa'ida kamar ayyuka masu yawa, tsafta da kwanciyar hankali, don haka abokan tarayya sun sansu sosai."

Yin Mafi Kyau

Bio-enzymes sunadaran sunadaran da ke da ayyuka masu kuzari, waɗanda suka bambanta da sauran sunadaran saboda suna da cibiyar aiki.API na bio-enzymes ana samun su ta hanyar rabuwa, cirewa da tsarkakewa daga kwayoyin halitta.

"Bio-enzyme API masana'antu ce mai babban jari, ƙarancin riba da babban haɗarin fasaha.Ma'aunin masana'antu kadan ne.Kuma akwai ƙananan kamfanoni da ke tsunduma a ciki. "A cewar Zhang Ge, babban hadarin fasaha ya faru ne saboda ayyukan enzymes da ke sa aikin tsarkakewa ya fi wahala.Misali, idan tsarin ba a sarrafa shi da kyau, samfurin na iya samun wani aiki, sannan ya rasa ƙimar magani.

Bio-enzyme API yana ɗaya daga cikin albarkatun albarkatun bio-pharmaceuticals.Tare da ƙananan ƙwayar cuta da sakamako masu illa, magungunan bio-pharmaceuticals suna da niyya sosai don maganin wasu cututtuka kuma jikin ɗan adam yana ɗauka cikin sauƙi.Yana da tasirin warkewa na musamman don ciwon sukari, cututtukan zuciya, ciwace-ciwace da cututtukan hoto.

"Tafiyata falsafar ita ce muddin na yi abin da wasu ba su yi ba, na yi mafi kyau."Zhang Ge ya yi imanin cewa, dalilin da ya sa ya kafu a cikin masana'antar bio-enzyme fiye da shekaru 20 shine ƙaunar da yake da ita ga enzymes.A shekarar 1990, bayan kammala karatunsa daga Jami'ar Sichuan (Tsohuwar Jami'ar Kimiyya da Fasaha ta Chengdu) da ke karatun kimiyyar halittu, Zhang Ge ya yi aiki a matsayin masaninsa, daga baya kuma ya yi aiki a matsayin darektan dakin gwaje-gwaje a masana'antar harhada magunguna ta Deyang Biochemical.Bayan shekaru biyar, saboda sake fasalin masana'anta, ya karbi aikin.

“A wancan lokacin, masana’antar biochemical ta kusa rikidewa zuwa kamfanin harhada magunguna.Na je masana’anta na duba sai na ga wasu tsirarun matasa suna gyara wata karamar tsohuwar bita.Fuskokinsu a rufe da ruwa da laka.Daga cikinsu akwai Zhang Ge."Zhong Guangde, tsohon mataimakin darektan hukumar kula da kiwon lafiya ta lardin Sichuan, ya tuna da cewa, "Har yanzu Zhang Ge shi ne saurayi yana yin abubuwa masu amfani a idona."

A watan Disamba na shekarar 1994, Zhang Ge ya kafa kamfanin Sichuan Deyang Biochemical Products Co., Ltd. Da zarar an kafa shi, ya kusa yin fatara.

"A farkon shekarun 1990, fahimtar ingancin masana'antar Bio-enzyme ta kasar Sin gaba daya ba ta da karfi, kuma fahimtarmu game da enzymes har yanzu tana da iyaka saboda sanin cewa aikin enzyme mai kyau ya isa."A cewar Zhang Ge, a cikin watan Maris na shekarar 1995, sabuwar kafa ta Deyang Biochemical Products Co., Ltd. ta samu odar farko ta danyen kallidinogenase don fitarwa zuwa kasuwannin Japan.Koyaya, an ƙi samfuran saboda bambancin ƴan milligrams a cikin abun ciki mai mai.“Idan dayan bangaren suka nemi a biya su diyya, kamfanin zai yi fatara, kuma adadin diyya ya kasance na taurari ne ga kamfanin a lokacin.Abin farin ciki, ta hanyar haɗin kai, ɗayan jam'iyyar ba ta nemi mu ba mu ramuwa ba amma bari mu sake samar da samfuran, "in ji Zhang Ge.

Wannan kwarewa ta koyar da Zhang Ge, wanda ke fara kasuwanci, wani muhimmin darasi kuma ya sa ya gane cewa ingancin kayayyaki shi ne rayuwar kamfani.A cikin shekaru 27 masu zuwa na ci gaba, kamfanin koyaushe yana bin ka'idoji masu inganci.Dangane da shekaru na bincike na asali, Deebio ya ci gaba da inganta fasaharsa, ta haka ne ya haifar da kariyar ayyukan enzyme mai cikakken tsari, kunnawa mara lalacewa da ainihin fasahar tsarkakewa don tabbatar da babban aiki, babban tsabta da kwanciyar hankali na samfurori na Bio-enzyme API.

Tsayawa Babu Ƙoƙari don Saka hannun jari a cikin ƙididdigewa

“Masana'antar bio-enzyme API tana da ƙarancin ƙima da haɓakawa.Ba tare da haɓakar fasaha ba, samfur ɗaya ko biyu ba za su iya tallafawa kamfani don haɓakawa ba.Deebio yana da samfur guda ɗaya tun lokacin da aka kafa shi.Amma a yau akwai APIs sama da dozin na bio-enzyme, waɗanda ba za a iya raba su da ci gaba da saka hannun jarinmu a fasaha ba.”Zhang Ge ya ce.

Trypsin-Chymotrypsin wani enzyme proteolytic ne wanda aka rabu kuma an tsarkake shi daga ƙwayar porcine.Yana ɗaya daga cikin manyan samfuran Deebio.R&D na wannan samfur ya amfana daga haɗin gwiwar binciken masana'antu-jami'a.A shekara ta 1963, Qi Zhengwu, wani mai bincike a cibiyar nazarin ilimin halittar jiki da ilmin halittu ta Shanghai na kwalejin kimiyya ta kasar Sin, ya yi amfani da recrystallization wajen fitar da wani hadadden kristal na chymotrypsin da trypsin daga naman alade, wanda ake kira trypsin-chymotrypsin.Wannan enzyme bai kasance masana'antu ba fiye da shekaru 30.Zhang Ge ya ga dama a ciki."A cikin 1997, mun ba da hadin kai tare da rukunin bincike na masanin kimiyya Qi Zhengwu don fahimtar masana'antu na trypsin-chymotrypsin tare da samun fa'ida mai kyau na tattalin arziki da zamantakewa.A mafi kyawun lokacinsa, sama da ton 20 na wannan samfurin ana fitar dashi zuwa Indiya. "A cewar Zhang Ge, masanin ilmin kimiyya Qi Zhengwu ya yi nuni da cewa, "Abin mamaki, kayayyakina sun kasance masana'antu ta hanyar masana'antu na gari da na kauyuka."

Bayan ɗanɗano daɗin kirkire-kirkire na fasaha, Deebio ya ƙara haɓaka jarin da yake zubawa a fannin fasaha, ya kuma ɓullo da haɗin gwiwar masana'antu da jami'o'in bincike-bincike tare da jami'ar Tsinghua, da kwalejin kimiyya ta kasar Sin, da jami'ar Sichuan, da jami'ar harhada magunguna ta kasar Sin, da sauran cibiyoyin ilimi da bincike na ilimi. , don haɗin gwiwar gina dakunan gwaje-gwaje, ci gaba da inganta binciken kimiyyar ƙungiyar da ƙwarewar ƙirƙira da kuma gina ƙungiyar samarwa da R&D tare da babban ƙarfin canjin fasaha wanda ya sami nasarar samun fasahar ƙetare 15.

Domin kara inganta ingancin kayayyaki, a shekarar 2003, Deebio ya hada kai da wani abokin huldar kasar Jamus da ke da fasahar zamani da karfin gudanarwa don kafa wani kamfani na hadin gwiwa mai suna Deyang Sinozyme Pharmaceutical Co., Ltd. "A wannan shekarar, mun zuba jari fiye da yuan miliyan 20. don gina sabon shuka, tare da gina kayan aikin samarwa tare da manyan kayan duniya.A daidai wannan lokacin, ana iya gina masana'anta a kasar Sin kan yuan miliyan 5.Kudin gina Sinozyme daidai yake da na masana'antu 4."A cewar Zhang Ge, abokin tarayya na Jamus ya ziyarci kamfanin don ba da jagoranci na kwanaki goma a kowane wata.Tare da gabatar da hanyoyin sarrafa ingantaccen tsarin inganci, an haɓaka ikon sarrafa tsarin Sinozyme zuwa matakin mafi girma na duniya.

A cikin 2005, Sinozyme ya zama kamfani na farko na pancreatin na kasar Sin don samun takardar shedar EU-GMP;a 2011, Sichuan Deebio Pharmaceutical Co., Ltd. aka kafa;a cikin 2012, Deebio ya sami takardar shedar CN-GMP;a cikin Janairu 2021, an kafa Deebio (Chengdu) Bio-technology Co., Ltd. don R&D, samarwa da aikace-aikacen manyan magunguna da shirye-shiryen enzyme na biotechnology.

"Ina ganin ya kamata kamfanoni su kasance a shirye su zuba jari a samar da fasahar kere-kere.Deebio ya gina sabuwar masana'anta duk shekara 7 zuwa 8.A cikin waɗannan shekarun, yawancin ribar an saka hannun jari a cikin ginin masana'antu, canjin kayan aikin samarwa da gabatarwar gwaninta.Masu hannun jari da manajoji suna samun ƴan riba kaɗan.”Zhang Ge, wanda ya taba zama injiniya, ya fahimci mahimmancin saka hannun jari a fannin fasaha.Ya ci gaba da tafiyar da sabbin abubuwa, kuma ya jera jerin abubuwan da za a yi: Sabon taron GMP na Deebio wanda aka gina bisa ka'idojin FDA an fara shi ne a bara kuma ana sa ran kammala shi a karshen watan Mayu kuma ya shiga samar da gwaji;Deebio (Chengdu) Bio-technology Co., Ltd., dake Wenjiang, Chengdu, a hukumance ya fara ginin a ranar 26 ga Afrilu kuma ana sa ran fara amfani da shi a hukumance a watan Oktoba.

"Green Production shine Abin da Nafi Alfahari da shi"

Gurbacewar API ta kasance abin damuwa ga al'umma koyaushe, kuma kare muhalli ya zama babban tashin hankali wanda ke ƙayyade rayuwar kamfanoni.Riko da samar da kore shi ne abin da Zhang Ge ya fi alfahari da shi.

“A lokacin farkon ci gaban kamfanin, ba mu mai da hankali sosai kan lamuran muhalli ba.Amma daga baya, yayin da kasar ta gabatar da bukatun kare muhalli, mun fara fahimtar mahimmancinsa."A cewar Zhang Ge, a cikin shekaru goma da suka gabata, Deebio ya mai da hankali sosai kan hakan, tare da kokarin samun ci gaba mai dorewa.

Lamarin da ya haifar da sauyin.“A taron da aka yi shekaru da yawa da suka gabata, shugabannin kamfaninmu suna shirin samar da wani samfurin da ke buƙatar wasu reagents na sinadarai.Daya daga cikin reagents na sinadarai ba zai iya lalacewa ba kuma, idan aka zubar da ruwan datti a cikin kogin, yana iya haifar da nakasu ga jarirai.Ba ni da wata shakka in ce a'a ga wannan samfurin."Da yake magana game da lamarin, Zhang Ge ya yi matukar bacin rai, “Garina na kusa da kogin Tuojiang, wanda ke da nisan sama da kilomita 200 daga birnin Guanghan na lardin Sichuan.Kuma kogin da ke kusa da masana'antarmu yana gudana cikin kogin Tuojiang.Fitar da ruwa kai tsaye laifi ne ga al'umma masu zuwa.Don haka ba zan yi irin wannan abu ba.”

Tun daga wannan lokacin, Deebio ya ba da shawarar cewa idan har tsarin samar da kayayyaki ya ƙunshi albarkatun ƙasa masu guba da haɗari masu haɗari ko kayan taimako waɗanda ba za a iya sarrafa su ba wajen haɓaka sabbin kayayyaki, ba za a ba da izinin ci gaba ba, kuma ya dage kan saka hannun jari don kare muhalli don kare muhalli. sama da shekaru goma.

A yau, Deebio ya gina cibiyar kula da ruwan sharar gida mai nau'in lambu tare da karfin jiyya na yau da kullun na 1,000m³, tare da fitar da ruwan sharar bayan ya kai matsayin.“Wannan karfin ya ishe mu mu yi amfani da shi tsawon shekaru goma.Kuma an gina wani lambu musamman akan cibiyar kula da ruwan sha.Za a iya amfani da ruwan da aka sarrafa don kiwon kifi da furannin ruwa,” in ji Zhang Ge cikin alfahari.

Bugu da kari, ana iya magance matsalar iskar gas ta hanyar feshi da sauran hanyoyin, kuma ana iya amfani da iskar gas din don dumama tukunyar jirgi bayan zubar da ruwa, ta yadda za a adana 800m³ na iskar gas a kowace rana.Don daskararrun da aka samar, akwai ƙaƙƙarfan bita na musamman.Ana juya sharar furotin ta zama takin halitta a cikin mintuna 4 ta na'urar bushewa kuma ana tura shi zuwa shukar taki.

Zhang Ge ya ce cikin motsin rai, "Yanzu duk yankin shuka ba ya samar da wani wari na musamman, kuma ana sarrafa ruwan sharar gida da gurbacewar yanayi bisa tsari.Ina alfahari da wannan fiye da samar da kayayyaki, wanda shine nasarar da na fi daraja."

Game da ci gaban nan gaba, Zhang Ge yana da kwarin gwiwa, "Ci gaban masana'antu na bukatar ci gaba mai dorewa.Babban haɓakar haɓakar masana'antar bio-enzyme API yana nufin ba wai kawai samar da samfuran inganci ba, har ma da samun ƙarin fasahar ci gaba, ingantaccen aiki, buƙatun gudanarwa, da ƙarin hanyoyin samar da muhalli.Deebio zai ɗauki jagorancin ingantacciyar ci gaban masana'antar a matsayin alhakinsa, kuma da zuciya ɗaya zai yi hidima ga dukkan bil'adama don lafiyarsu a kan hanyar ci gaba mai inganci."